WHere do B cells proliferate and differentiate into plasma cells?
Answer by ^^
growing stage in bone marrow.. but poliferate and differentaite upon recognizing foreign substance.... the location is anywhere as long as there is blood and capiliary gap for b cells to move
Answer by Mr. Biology
Activation of B cells:
1. Capping: The serial (many repeated forms of antigens) antigenic determinants bind to several antibodies on the surface of the B cell. Pulling the antibodies together. The B cell is activated when this whole cluster is ingested by the cell.
2. Help from specialized T cells: Helper T cells release a chemical called interleukin II. This double action ( antigen and interleukin II) results in a clone of plasma cells, which secrete antibodies against the free antigens.
Each B cell is coated with only one type of receptor. They are considered selective in nature. Once an activated B cell begins to grow and multiply, this clone includes memory cells and effectors cells called plasma cells. B cells secrete very few antibodies but the plasma calls give off as many as 2000 antibodies per sec. for their 4-5 day life span.
Antibody Structure: Antibodies constitute a class of plasma proteins called Immunoglobulins, abbreviated Ig. These antibodies have the ability to recognize and help destroy specific antigens in the body. Each molecule consists of 2 distinct regions. a). the variable region (V) and b). the constant region(C).
A typical antibody consists of 2 pairs of polypeptide chains- 2 short identical light (L) chains and 2 longer identical heavy (H) chains. The chains are joined by disulfide bridges and noncovalent associations to form a Y shaped molecule. The ends of the Y contain the antigen binding sites.
Answer by stephanie_desouza
germinal centres of lymph nodes
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